• Most common pregnancy-induced liver disorder,
second commonest cause of jaundice in pregnancy
(viral hepatitis is the commonest cause worldwide))
• Anorexia, malaise, steatorrhoea, epigastric discomfort and dark urine may be present.
• Serum bile acid concentrations are markedly raised.
Conjugated bilirubin and liver enzymes are also raised.
• Ursodeoxycholic acid reverses biochemical abnormalities but no
evidence that it alters fetal outcome.
Not licensed for use in pregnancy
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