PCOS - Long-term consequences

1. Increased incidence of multiple pregnancy following ovulation induction
2. Increased incidence of gestational diabetes
3. Increased incidence of pregnancy induced hypertension
4. Increased risk of endometrial cancer -5-fold
5. Cardiovascular disease -mortality is not significantly increased although women with PCOS have abnormal lipid profiles
6. Increased risk of adult onset diabetes mellitus ~ 40% risk of NIDDM by the age of 40 years