Luteal phase defect

- Luteal-phase defect is a defect of progesterone secretion by the corpus luteum or a defect in endometrial response to hormonal stimulation, resulting in an inadequate endometrium for implantation

- Affects 3–20% of the infertile population and 23–60% of women with recurrent miscarriage

- Its role as a cause of infertility has been questioned and the benefit of treatment on pregnancy rates has not been established

- Women should not be offered an endometrial biopsy to evaluate the luteal phase as part of the investigation of fertility