Secondary amenorrhoea - causes

• Auto-immune diseases such as 

1. Addison's disease, 
2. thyroid disease and 
3. diabetes mellitus 

are associated with premature ovarian failure. 

In addition, any severe endocrine disorder can cause amenorrhoea
• The Down's syndrome female has ovaries containing a reduced number of smaIl follicles, which have a greatly increased rate of atresia
• Bulimia & anorexia nervosa associated with secondary amenorrhoea
  (Androgen insensitivity syndrome associated with primary amenorrhoea)