Medical disorders in pregnancy

• Sickle cell disease - complications are more common in pregnancy and ~35% of pregnancies will develop crises
• Eisenmenger's syndrome - atrial or ventricular septal defect with pulmonary hypertension and right-to-left shunt.

- Cyanotic heart disease with ~50% mortality in pregnancy
• Multiple sclerosis is less likely to present for the first time and less likely to relapse during pregnancy