WHO Group 2 ovulation disorders

Hypothalamic pituitary dysfunction (Normogonadotrophic-normoestrogenic)

Characterised by

• Gonadotrophin disorder
• Normal oestrogen

 

• Accounts for ~ 85% of ovulatory disorders
• Results in anovulatory oligo/amenorrhea, predominately involving women with polycystic ovaries.
• Polycystic ovaries are present in about 80–90% of women with oligomenorrhoea and 30% of women with amenorrhoea.
• In women with polycystic ovaries and clinical symptoms (menstrual disturbances, obesity and hyperandrogenism), this combination is referred to as PCOS.
• About 30% of the PCOS population is of normal weight

• The diagnosis of a polycystic ovary requires the presence of at least 12 follicles measuring 2–9 mm in diameter and/or an ovarian volume in excess of 10 cm3

The diagnosis of PCOS requires the presence at least two of the following three criteria

1. Oligo- and/or anovulation
2. Clinical and/or biochemical hyperandrogenism
3. Polycystic ovaries, with the exclusion of other aetiologies.