- LMWHs are more effective, are associated with a lower risk of
haemorrhage and lower mortality than unfractionated heparin in the
initial treatment of DVT in nonpregnant women.
- LMWHs are as effective as
unfractionated heparin in the initial treatment of PE.
- LMWHs associated with a lower risk of heparin-induced thrombocytopaenia and osteoporosis compared to unfractionated heparin
- LMWH should be given daily in two subcutaneous divided doses (in
view of recognised alterations in the pharmacokinetics of dalteparin
and enoxaparin during pregnancy) titrated against the woman’s booking or
most recent weight.
- Tinzaparin may be administered once daily.
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