Tuesday, August 13, 2013

WHO classification of ovulation disorders

Patients are classified as :

WHO-1  - hypo-gonadotropic, hypo-estrogenic, (15%)

WHO-2  - normo-gonadotropic, normo-estrogenic, (80%) and 

WHO-3 - hyper-gonadotropic, hypo-estrogenic (5%)


( Class 1 has hypothalamic-pituitary failure
  Class 2 has hypothalamic-pituitary-ovarian axis dysfunction
  Class 3 has ovarian failure )



 The WHO criteria for classification of anovulation include :
the determination of -
- oligomenorrea (menstrual cycle >35 days) or 
- amenorrhoea (menstrual cycle > 6 months) in combination with -concentration of prolactin, follicle stimulating hormone (FSH) and estradiol (E2). 

  The vast majority of anovulation patients belong to the WHO-2 group and demonstrate very heterogeneous symptoms ranging from anovulation, obesity, biochemical or clinical hyperandrogenism and insulin resistance.


3 comments:

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