- Affects 1-2:10,000 pregnancies
- Auto-antibodies against platelet surface antigens cause platelet destruction by the reticulo-endothelial system
- Diagnosis is one of exclusion after other causes of thrombocytopaenia
have been rulled out.
- Specialised labs may measure anti-platelet
antibodies
- Assay for anti-platelet antibodies not widely available and not useful in assessing disease severity
- Course of disease not affected by pregnancy
- IgG may cross the placenta and cause fetal thrombocytopaenia - fetal risks are, however, small
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