Metformin in PCOS

• Weight not significantly altered by metformin treatment

• Blood pressure - both systolic and diastolic blood pressure significantly reduced with metformin compared to placebo
• Fasting insulin significantly reduced
• Total cholesterol unchanged but LDL cholesterol significantly reduced. HDL cholesterol and triglycerides unaffected

• GI side-effects more common with metformin, particularly nausea and vomiting.