- Presents with clusters of vesicles and bullae and is associated with other auto-immune diseases and HLA-B8 and DR3
- Starts within umbilicus and spreads to involve limbs, palms and soles
- May improve in later pregnancy but 50-75% experience exacerbation within 24-48 hours of delivery
- 5% of neonates may develop bullous lesions
- Possible increased risk of adverse perinatal outcome - fetal growth and well-being should be monitored
- Treatment is with topical corticosteroids and oral anti-histamines or oral
prednisolone in severe cases in pregnancy although methotrexate and
azathioprine are used in non-pregnant.
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