Mifepristone

- Derivative of norethindrone (19-norsteroid) -similar chemical structure to progesterone / glucocorticoids.

- Progesterone / glucocorticoid antagonist
Glucocorticoid axis

- Glucocorticoid antagonist

- Inhibit negative feed-back of cortisol on ACTH secretion resulting in a significant increase in ACTH and cortisol after single 100mg dose.
SIDE-EFFECTS :

Vaginal bleeding, 
Malaise, 
Headache, 
Nausea, 
Vomiting, 
Rash