1. Ophthalmoplegia, nystagmus
2. Unsteady gait, ataxia
3. Mental status changes
- Rare but serious complication of hyperemesis gravidarum.
- Underlying thiamine (B1) deficiency causes alterations in carbohydrate metabolism -----> lactic acidosis -----> cerebral damage
Thiamine, also called B1, helps to breakdown glucose. Specifically, it acts as an essential coenzyme to the TCA cycle and the pentose phosphate shunt. Thiamine is first metabolised to its more active form, thiamine diphosphate (TDP), before it is used. The body only has 2–3 weeks of thiamine reserves, which are readily exhausted without intake, or if depletion occurs rapidly.
- Rx
I.V. diluted - 3 times a day x 2 days, followed by once a day x 5 days
- A case report
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